Tags
ancient DNA, cold winters, Davide Piffer, ethnicity, IQ, John Hawks, Michael Woodley, mutations, Neanderthals, polygenic scores, race, Richard Lynn
I am extremely honored that Davide Piffer (who has a blog) was kind enough to give our community an exclusive interview. While the leading geneticists in academia have explained only about 10% of the variance in IQ (or its proxy education) at the individual level, Piffer working on his own has reported near perfect correlations between the mean IQs of entire ethnic groups and their polygenic scores, making him a rock star in the HBD community. Virtually no one else on the planet is doing this kind of cutting edge research (at least not publicly).
In retrospect it makes perfect sense that aggregated data should correlate much better than individual level data. Imagine you visited every country in Eurasia and asked only the first person you met in each country their height. Such a small sample size (n = 1) from each country would tell you nothing about which individual country was taller than which, but if you averaged all the heights from the European countries and compared them to the average heights from the Asian countries, you’d learn a lot about which continent was taller. That’s because the small sample size at the level of individual countries is multiplied by the large sample of countries in each continent.
It’s the same with genomically predicting IQ. The small sample of single nucleotide polymorphisms (SNPs) sampled in each individual is multiplied by the large number of individuals sampled in each ethnic group, so while individual predictions are weak, group predictions are strong because individual error cancels out in the aggregate.
Below is my exclusive interview with Piffer. The interview has been lightly edited to remove typos and other mistakes. I began by asking him about table 5 in a 2019 paper he wrote. My statements are in red, while Davide’s are in blue.
PP: I’m very impressed by your work. But the correlation between PG score & mean IQ is so high in table 5 of Piffer (2019) that it seems too perfect. What would you say to skeptics who think you cherry-picked SNPs or manipulated your formulas to get such perfect results?
DP: Thanks. I didn’t cherry pick SNPs. I used the polygenic score provided by Lee et al and you can see that different PGS construction methods lead to same results… I used EA, EA Mtag, etc, weighted and unweighted..they all give same results. Also my paper replicates my previous findings and what I had predicted from theory years ago. The IQs aren’t cherry picked either because I used the same as I used in previous papers to avoid post hoc results.
PP: In table 1 of Piffer (2019), Peruvians & Colombians seem to have higher polygenic scores than the black populations, yet in Figure 11, Africa scores higher than the Americas. So who has higher polygenic scores: sub-Saharan Africans or Amerindians?
DP: Peruvian and Colombian aren’t pure. They are substantially mixed with Europeans. The groups in figure 11 are natives, so they better reflect the unadmixed population. Also the latter are from low coverage genomes with fewer markers so less reliable. I am working on a high coverage version of same datasets but it will take a while due to my limited funds.
Do you have some basic experience in bioinformatics? I am just looking for someone who could run the code on their laptop because it’s taking me a week to impute each chromosome. So I need to run it on multiple computers. But hey no bother…I will do it myself, it will just take it longer.
PP: No sadly I do not have experience with bioinformatics. But I can ask my blog & twitter readers if anyone has such experience and is willing to volunteer their time.
On table 5 of Piffer (2019) the African American PGS (GWAS sig) is 1.836 lower than the NW European PGS. But since African Americans are only 76% non-white (Bryc et al. 2015), can we roughly infer that un-mixed blacks would be 1.836/0.76 = 2.416 below NW Europeans, giving them a PGS score of 46.834?
DP: yes…also you have unmixed native Africans in the other tables. Kenyans, Yoruba, Mende Sierra Leone, etc
PP: In table 5 Latinos have a PGS (GWAS sig.) of 48.654. Do you think this could be used to estimate the PGS of unmixed Amerindians because according to Bryc et al, 2015, Latino Americans are 65.1% white (mostly southern European), 6.2% black, 18% Amerindian, and 11% unassigned, though the unassigned is broader East Asian/Amerindian so should probably be counted as Amerindian. Since you report the PGS for Southern Europeans and since I estimate the the PGS for pure blacks at 46.834, using simple algebra, I estimate unmixed Amerindians would have a PGS of 47.510.
DP: yes, but you should also cross-check these with the other table with scores for Peruvians and Mexicans and see if they converge.
PP: Good point. In one of your data sets you find a 0.57 correlation between PGS and latitude. Do you agree with Lynn’s cold winter theory of how racial differences in intelligence evolved?
DP: in part, yes. but it doesn’t explain the low Amerindian IQ because Native Americans were in Siberia during the Last Glacial Maximum and then they moved to North America at the end of it, which is also a cold region…So I think most of the differences are due to farming and civilization
PP: Well Lynn argues the anomalies can all be explained by population size. Low population races like Arctic people, Amerindians, Australoids, Bushmen, & pygmies have lower IQs than their climates predict because there weren’t enough positive mutations. Meanwhile high population races like East Asians, whites, South Asians, and West Africans have higher IQs than their climates predict. This would also explain why Neanderthals had lower IQs than their climates predict.
DP: but these SNPs are common among the races..the differences are explained by these common SNPs, not pop specific mutations. pop size is probably related to it through higher competition for resources selecting for higher IQ.
PP: I see…so then it was probably farming and civilization as you say. Just as cold climate boosted IQ because it was a novel environment to adapt to, so was farming, civilization and the literacy and numeracy requirements it imposed. Of course Amerindians also independently created civilization but most remained hunter-gatherers.
DP: yes… plus we don’t know how many of these SNPs are just life history or personality traits like C. stuff that farming selected for. most of them are related to g but a subset will also be related to conscientiousness. Emil et al in their Psych paper vetted their association with g in a sample though so I guess they must be genuine associations with IQ for the most part.
PP: Yes, because no one has given a huge sample (n = 1 million) of genotyped people a highly g loaded test. A perfect study would get a sample of 1 million people (from all over the world) and give them an extremely culture reduced test with many subtests to maximize g loading (i.e. block design, draw a person in the sand, name as many body parts as you can in 1 minute in your own language, pictorial oddities etc) and then enter the composite score, DNA and human development index of each person into a computer and have machine learning create a multiple regression equation predicting IQ using HDI & genomic variants as independent variables. By using such a diverse and global sample, one finds the genomic variants that correlate with IQ everywhere and thus are most likely to be causal.
DP: yes.
PP: Now that the neanderthal genome has been published, why haven’t you tried to estimate their polygenic score? Richard Klein argues that before about 50 kya, modern humans and neanderthals had similar intellect, but suddenly around 50 kya there was a genetic brain change that allowed modern humans to leave Africa, colonize every continent, replace neanderthals & invent art & complex technology. Testing this hypothesis was the main motivation to sequence the neanderthal genome so there’s enormous interest in their intelligence, even in mainstream science.
DP: yes that’s the next step…we’re analyzing genomes from Bronze age now, but Neanderthal would be good. But funds are limited for this kind of research and I am not working in academia.
PP: Above you rejected Lynn’s population size mutation theory on the grounds that all races have all the known IQ related genomic variants, however it also seems you have no high coverage genomes from low population isolated groups like pygmies, bushmen, australoids, arctic people & pure Amerindians. Is it plausible that high coverage genomes of these groups would show they are missing some of the IQ enhancing mutations that appeared in the last 15,000 years?
DP: What I am saying is that you can see a difference even at the common SNPs in their frequencies. I cannot rule out that they are also missing these mutations but that would be an additional factor.
PP: Do you agree with John Hawks’s theory that positive selection in the last 5000 years has been a hundred times faster than in any other period of human evolution because of the explosion of new mutations & environmental change? This is the exact opposite of Gould who argued we have the same bodies and brains we’ve had 40,000 years ago and all subsequent change has been cultural not biological.
DP: from a purely theoretical point of view, yes, but one would need to study ancient genomes to empirically vet that hypothesis.
PP: Is there any strong evidence in support of Michael Woodley’s theory that white genomic IQ has declined by 10 or 15 IQ points since the Victorian era?
DP: I computed the decline based on the paper by Abdellaoui on British [Education Attainment] PGS and social stratification and it’s about 0.3 points per decade, so about 3 points over a century.
It’s not necessarily the case that IQ PGS declined more than the EA PGS..if anything, the latter was declining more because dysgenics on IQ is mainly via education so I think 3 points per century is a solid estimate
Thank you Davide Piffer for this interview. As mentioned above, you can find more of Davide’s thoughts on his blog.
